The plausible mechanisms of action of Carica papaya on Dengue infection: A comprehensive review
Dengue is a serious health endemic with a prediction that 2.5 billion are at risk of acquiring dengue infection and 50 million are infected yearly. Over the years, tremendous effort has been done to develop potential treatment for dengue infection. However, to no avail, most of the treatment modalities have failed in clinical evaluation and trials. With the lack of treatment for dengue infection, home remedies have been widely used as a belief to relieve the symptoms, one of them is the use of papaya leaf juice. This review provides a recent evidences and research that have been attempted to unravel the mechanism of actions of papaya leaf extract to treat dengue infection. Up to date, there are three main mechanisms that have been proposed, which are the anti-thrombocytopenic, immunomodulatory and anti-viral effect of papaya leaf juice extract.
Copyright (c) 2020 Zhui Ken Bok, Manisha Balakrishnan, Yong Xin Jong, Yew Rong Kong, Kooi Yeong Khaw, Yong Sze Ong
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