https://journals.hh-publisher.com/index.php/pddbs/issue/feed 2025-05-04T16:02:06+08:00 PDDBS Editorial Office inquiries@hh-publisher.com Open Journal Systems <table style="height: 490px; width: 609px;"> <tbody> <tr style="height: 58px;"> <td style="width: 243px; height: 58px;"> <img src="http://journals.hh-publisher.com/public/journals/3/journalThumbnail_en_US.jpg" alt="" width="220" height="300" /></td> <td style="width: 358px; height: 124px;" rowspan="2"> <p style="text-align: justify;"><strong><em>Progress in Drug Discovery &amp; Biomedical Science (PDDBS)</em></strong><em> </em>is<em> </em>an open access journal dedicated to the exchange of information and understandings about the research in areas of drug discovery and biomedical science based on the principles established through international conventions.</p> <p class="p" style="text-align: justify;" align="justify"><strong><em>PDDBS </em></strong>covering both the fundamental and application aspects of drug discovery &amp; biomedical science and welcoming papers having a good interdisciplinary approach.</p> <p class="p" style="text-align: justify;" align="justify">Coverage includes:</p> <p class="p" style="text-align: justify;" align="justify">- Plant, microbes bioactives</p> <p class="p" style="text-align: justify;" align="justify">- Basic or applied biomedical research</p> <p class="p" style="text-align: justify;" align="justify">- Toxicology &amp; pharmacology</p> <p class="p" style="text-align: justify;" align="justify">-<strong> </strong>Molecular/cell biology</p> <p class="p" style="text-align: justify;" align="justify">- Drug delivery</p> <p class="p" style="text-align: justify;" align="justify">- Therapeutic strategies/targets</p> <p class="p" style="text-align: justify;" align="justify">- ADME</p> <p class="p" style="text-align: justify;" align="justify">- Clinical trials</p> <p class="p" align="justify">- Structural Biology and Biomolecular Modeling</p> <p class="p" align="justify">- Curriculum, instruction and pedagogy</p> </td> </tr> <tr style="height: 66px;"> <td style="width: 243px; height: 66px;"> </td> </tr> </tbody> </table> <p style="text-align: Left;"><em><strong><a href="http://journals.hh-publisher.com/index.php/pddbs/about/submissions">ONLINE SUBMISSION</a></strong> </em></p> https://journals.hh-publisher.com/index.php/pddbs/article/view/1157 2025-05-04T16:02:06+08:00 Rachel Xue-Yu Teoh nancyc@sunway.edu.my Nancy Choon-Si Ng nancyc@sunway.edu.my Rebecca Shin-Yee Wong nancyc@sunway.edu.my

<p>Prader-Willi Syndrome is a rare neurodevelopmental genetic disorder resulting from expression defects of the exclusively paternally-expressed PWS locus at chromosome 15q11-q13. Even though its multifaceted manifestations and potentially fatal comorbidities poses universal concern, it remains incurable. Thus, this commentary applies a health impact assessment framework to evaluate the potential behind CRISPR-Cas9 gene-editing technology as a therapeutic intervention for PWS. While this novel technique displays outstanding precision and effectiveness in the targeted identification and demethylation of the silenced maternal locus, challenges such as off-target mutations, safety, and ethical implications warrant additional improvements. Therefore, recommendations regarding future research and clinical implementation are also proposed.</p>

2025-05-04T00:00:00+08:00 Copyright (c) 2025 Rachel Xue-Yu Teoh, Nancy Choon-Si Ng, Rebecca Shin-Yee Wong